Neuroregeneration in neurodegenerative disorders
نویسندگان
چکیده
BACKGROUND Neuroregeneration is a relatively recent concept that includes neurogenesis, neuroplasticity, and neurorestoration--implantation of viable cells as a therapeutical approach. DISCUSSION Neurogenesis and neuroplasticity are impaired in brains of patients suffering from Alzheimer's Disease or Parkinson's Disease and correlate with low endogenous protection, as a result of a diminished growth factors expression. However, we hypothesize that the brain possesses, at least in early and medium stages of disease, a "neuroregenerative reserve", that could be exploited by growth factors or stem cells-neurorestoration therapies. SUMMARY In this paper we review the current data regarding all three aspects of neuroregeneration in Alzheimer's Disease and Parkinson's Disease.
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1College of Medicine, University of Central Florida, Orlando, FL 32827, USA 2Eve Topf and US National Parkinson Foundation, Centers of Excellence for Neurodegenerative Diseases Research and Teaching, Technion-Rappaport Faculty of Medicine, Haifa, Israel 3Department of Biology, Yonsei University, Seoul, Republic of Korea 4Karolinska Institutet, Alzheimer Neurobiology Center, Karolinska Universit...
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